PEGylated Nano-Graphene Oxide for Delivery of Water Insoluble Cancer Drugs

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dc.creatorLiu, Zhuang
dc.creatorRobinson, Joshua T.
dc.creatorSun, Xiaoming
dc.creatorDai, Hongjie
dc.date2008-07-30
dc.date.accessioned2026-07-07T09:53:56Z
dc.date.available2026-07-07T09:53:56Z
dc.descriptionIt is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nano-graphene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analog, SN38 non-covalently via pi-pi stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.
dc.identifierhttps://arxiv.org/abs/0807.4959
dc.identifierhttp://arxiv.org/abs/0807.4959
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/166134
dc.subjectMaterials Science
dc.subjectBiological Physics
dc.subjectTissues and Organs
dc.titlePEGylated Nano-Graphene Oxide for Delivery of Water Insoluble Cancer Drugs
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