BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite

Simple item page
dc.creatorBernard-Gallon, Dominique J
dc.creatorDéchelotte, Pierre
dc.creatorVissac, Cécile
dc.creatorAunoble, Bénédicte
dc.creatorCravello, Laetitia
dc.creatorMalpuech, Georges
dc.creatorBignon, Yves-Jean
dc.date2000-11-09
dc.date.accessioned2026-07-07T01:45:56Z
dc.date.available2026-07-07T01:45:56Z
dc.descriptionBRCA1 and BRCA2 breast cancer susceptibility genes encode proteins, the normal cellular functions of which are complex and multiple, and germ-line mutations in individuals predispose both to breast and to ovarian cancer. There is nevertheless substantial evidence linking BRCA1 and BRCA2 to homologous recombination and DNA repair, to transcriptional control and to tissue proliferation. There is controversy regarding the localization of BRCA1 and BRCA2 proteins to either nucleus or cytoplasm and whether the expression is present in premeiotic germ cells or can still be expressed in mitotic spermatogonia. We report herein an immunohistochemical study of BRCA1 and BRCA2 distribution in a rather unsual tissue (an ovotestis), which addresses this issue.
dc.identifierhttps://pmc.ncbi.nlm.nih.gov/articles/PMC13901/
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/11250747/
dc.identifierhttps://doi.org/10.1186/bcr272
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/136
dc.languageen
dc.publisherBMC
dc.rightsCopyright © 2000 BioMed Central Ltd on behalf of the copyright holders
dc.sourceBreast Cancer Res
dc.subjectPrimary Research
dc.titleBRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite
dc.typeText

Files

Collections

PubMed Central