Cell-permeable tumor suppressor peptides for cancer therapy: back to the future
| dc.creator | Radulescu, Razvan Tudor | |
| dc.date | 2007-11-29 | |
| dc.date.accessioned | 2026-07-07T08:46:10Z | |
| dc.date.available | 2026-07-07T08:46:10Z | |
| dc.description | Miniaturization is a hallmark of modern technologies. Notably, this feature has not spared molecular biology and its potential applications. Towards developing more effective therapeutics against cancer, studies began to explore more than a decade ago how natural tumor suppression could be translated into antineoplastic drugs. To this end, investigators focused on major constituents of a central pathway that protects cells against neoplastic transformation: the nuclear retinoblastoma protein (RB) pathway. As such, peptide mimetics of RB, p16 and p21 were developed. Likewise, the p53 and von Hippel-Lindau gene products which affect indirectly the RB pathway provided additional templates for the development of anti-proliferative peptides. Each of the peptides derived from these distinct tumor suppressors was made cell-permeable by its ligation to an amino acid sequence conferring cellular internalization. Details reviewed here reveal that through the application of such anti-cancer peptide therapeutics alone or in conjunction whenever synergy is to expect, the dark era of chemotherapy will likely be overcome, at last. | |
| dc.description | 6 pages | |
| dc.identifier | https://arxiv.org/abs/0711.4743 | |
| dc.identifier | http://arxiv.org/abs/0711.4743 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/143163 | |
| dc.subject | Biomolecules | |
| dc.subject | Subcellular Processes | |
| dc.title | Cell-permeable tumor suppressor peptides for cancer therapy: back to the future | |
| dc.type | text |