In silico evidence of the relationship between miRNAs and siRNAs

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dc.creatorMontanucci, Ludovica
dc.creatorFariselli, Piero
dc.creatorMartelli, Pier Luigi
dc.creatorRossi, Ivan
dc.creatorCasadio, Rita
dc.date2007-05-16
dc.date.accessioned2026-07-07T08:01:51Z
dc.date.available2026-07-07T08:01:51Z
dc.descriptionBoth short interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate the repression of specific sequences of mRNA through the RNA interference pathway. In the last years several experiments have supported the hypothesis that siRNAs and miRNAs may be functionally interchangeable, at least in cultured cells. In this work we verify that this hypothesis is also supported by a computational evidence. We show that a method specifically trained to predict the activity of the exogenous siRNAs assigns a high silencing level to experimentally determined human miRNAs. This result not only supports the idea of siRNAs and miRNAs equivalence but indicates that it is possible to use computational tools developed using synthetic small interference RNAs to investigate endogenous miRNAs.
dc.description8 pages, 2 figures
dc.identifierhttps://arxiv.org/abs/0705.2355
dc.identifierhttp://arxiv.org/abs/0705.2355
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/129046
dc.subjectBiomolecules
dc.subjectGenomics
dc.titleIn silico evidence of the relationship between miRNAs and siRNAs
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