Efficiency of initiating cell adhesion in hydrodynamic flow

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dc.creatorKorn, C.
dc.creatorSchwarz, U. S.
dc.date2006-09-05
dc.date.accessioned2026-07-07T07:23:25Z
dc.date.available2026-07-07T07:23:25Z
dc.descriptionWe theoretically investigate the efficiency of initial binding between a receptor-coated sphere and a ligand-coated wall in linear shear flow. The mean first passage time for binding decreases monotonically with increasing shear rate. Above a saturation threshold of the order of a few 100 receptor patches, the binding efficiency is enhanced only weakly by increasing their number and size, but strongly by increasing their height. This explains why white blood cells in the blood flow adhere through receptor patches localized to the tips of microvilli, and why malaria-infected red blood cells form elevated receptor patches (knobs).
dc.description4 pages, Revtex, 4 Postscript figures included, to appear in PRL
dc.identifierhttps://arxiv.org/abs/cond-mat/0609093
dc.identifierhttp://arxiv.org/abs/cond-mat/0609093
dc.identifierPhys. Rev. Lett. 97:138103 (2006)
dc.identifierdoi:10.1103/PhysRevLett.97.138103
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/115976
dc.subjectSoft Condensed Matter
dc.subjectMaterials Science
dc.subjectCell Behavior
dc.titleEfficiency of initiating cell adhesion in hydrodynamic flow
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