Limit Theorems for Hybridization Reactions on Oligonucleotide Microarrays

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dc.creatorRempala, Grzegorz A.
dc.creatorPawlikowska, Iwona
dc.date2008-02-08
dc.date.accessioned2026-07-07T09:19:36Z
dc.date.available2026-07-07T09:19:36Z
dc.descriptionWe derive herein the limiting laws for certain stationary distributions of birth-and-death processes related to the classical model of chemical adsorption-desorption reactions due to Langmuir. The model has been recently considered in the context of a hybridization reaction on an oligonucleotide DNA microarray. Our results imply that the truncated gamma- and beta- type distributions can be used as approximations to the observed distributions of the fluorescence readings of the oligo-probes on a microarray. These findings might be useful in developing new model-based, probe-specific methods of extracting target concentrations from array fluorescence readings.
dc.identifierhttps://arxiv.org/abs/0802.1192
dc.identifierhttp://arxiv.org/abs/0802.1192
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/154449
dc.subjectProbability
dc.subjectStatistics Theory
dc.subjectQuantitative Methods
dc.subject60F05, 60G35
dc.titleLimit Theorems for Hybridization Reactions on Oligonucleotide Microarrays
dc.typetext

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