Optimal experimental design in an EGFR signaling and down-regulation model

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dc.creatorCasey, Fergal P.
dc.creatorBaird, Dan
dc.creatorFeng, Qiyu
dc.creatorGutenkunst, Ryan N.
dc.creatorWaterfall, Joshua J.
dc.creatorMyers, Christopher R.
dc.creatorBrown, Kevin S.
dc.creatorCerione, Richard A.
dc.creatorSethna, James P.
dc.date2006-10-12
dc.date.accessioned2026-07-07T07:30:09Z
dc.date.available2026-07-07T07:30:09Z
dc.descriptionWe apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho family G protein Cdc42. The complex has been suggested to be important in disrupting receptor down-regulation. We demonstrate that the model interactions can accurately reproduce the experimental observations, that they can be used to make predictions with accompanying uncertainties, and that we can apply ideas of optimal experimental design to suggest new experiments that reduce the uncertainty on unmeasurable components of the system.
dc.description13 pages, 9 figures in main text. 7 pages, 7 figures in supplementary material. Submitted to IEE Proceedings Systems Biology
dc.identifierhttps://arxiv.org/abs/q-bio/0610024
dc.identifierhttp://arxiv.org/abs/q-bio/0610024
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/118368
dc.subjectMolecular Networks
dc.subjectQuantitative Methods
dc.titleOptimal experimental design in an EGFR signaling and down-regulation model
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