Estimating the proportion of differentially expressed genes in comparative DNA microarray experiments

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dc.creatorCabrera, Javier
dc.creatorYu, Ching-Ray
dc.date2007-08-07
dc.date.accessioned2026-07-07T08:24:35Z
dc.date.available2026-07-07T08:24:35Z
dc.descriptionDNA microarray experiments, a well-established experimental technique, aim at understanding the function of genes in some biological processes. One of the most common experiments in functional genomics research is to compare two groups of microarray data to determine which genes are differentially expressed. In this paper, we propose a methodology to estimate the proportion of differentially expressed genes in such experiments. We study the performance of our method in a simulation study where we compare it to other standard methods. Finally we compare the methods in real data from two toxicology experiments with mice.
dc.descriptionPublished at http://dx.doi.org/10.1214/074921707000000076 in the IMS Lecture Notes Monograph Series (http://www.imstat.org/publications/lecnotes.htm) by the Institute of Mathematical Statistics (http://www.imstat.org)
dc.identifierhttps://arxiv.org/abs/0708.0968
dc.identifierhttp://arxiv.org/abs/0708.0968
dc.identifierIMS Lecture Notes Monograph Series 2007, Vol. 54, 92-102
dc.identifierdoi:10.1214/074921707000000076
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/136385
dc.subjectMethodology
dc.titleEstimating the proportion of differentially expressed genes in comparative DNA microarray experiments
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