Towards local electromechanical probing of cellular and biomolecular systems in a liquid environment

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dc.creatorKalinin, Sergei V.
dc.creatorRodriguez, Brian J.
dc.creatorJesse, Stephen
dc.creatorSeal, Katyayani
dc.creatorProksch, Roger
dc.creatorHohlbauch, Sophia
dc.creatorRevenko, Irene
dc.creatorThompson, Gary Lee
dc.creatorVertegel, Alexey A.
dc.date2007-04-30
dc.date.accessioned2026-07-07T09:26:15Z
dc.date.available2026-07-07T09:26:15Z
dc.descriptionElectromechanical coupling is ubiquitous in biological systems with examples ranging from simple piezoelectricity in calcified and connective tissues to voltage-gated ion channels, energy storage in mitochondria, and electromechanical activity in cardiac myocytes and outer hair cell stereocilia. Piezoresponse force microscopy (PFM) has originally emerged as a technique to study electromechanical phenomena in ferroelectric materials, and in recent years, has been employed to study a broad range of non-ferroelectric polar materials, including piezoelectric biomaterials. At the same time, the technique has been extended from ambient to liquid imaging on model ferroelectric systems. Here, we present results on local electromechanical probing of several model cellular and biomolecular systems, including insulin and lysozyme amyloid fibrils, breast adenocarcinoma cells, and bacteriorhodopsin in a liquid environment. The specific features of SPM operation in liquid are delineated and bottlenecks on the route towards nanometer-resolution electromechanical imaging of biological systems are identified.
dc.description37 pages (including refs), 8 figures
dc.identifierhttps://arxiv.org/abs/0704.3958
dc.identifierhttp://arxiv.org/abs/0704.3958
dc.identifier2007 Nanotechnology 18 424020 (10pp)
dc.identifierdoi:10.1088/0957-4484/18/42/424020
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/156689
dc.subjectOther Condensed Matter
dc.subjectSoft Condensed Matter
dc.titleTowards local electromechanical probing of cellular and biomolecular systems in a liquid environment
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