Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics

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dc.creatorMorant, Pierre-Emmanuel
dc.creatorThommen, Quentin
dc.creatorLemaire, François
dc.creatorVandermoëre, Constant
dc.creatorParent, Benjamin
dc.creatorLefranc, Marc
dc.date2008-03-31
dc.date2009-01-12
dc.date.accessioned2026-07-07T12:43:09Z
dc.date.available2026-07-07T12:43:09Z
dc.descriptionWe revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.
dc.identifierhttps://arxiv.org/abs/0803.4415
dc.identifierhttp://arxiv.org/abs/0803.4415
dc.identifierPhysical Review Letters 102, 6 (2009) 068104
dc.identifierdoi:10.1103/PhysRevLett.102.068104
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/220323
dc.subjectQuantitative Methods
dc.subjectMolecular Networks
dc.titleOscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
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