Anomalous scaling in nanopore translocation of structured heteropolymers

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dc.creatorMcCauley, Malcolm
dc.creatorForties, Robert
dc.creatorGerland, Ulrich
dc.creatorBundschuh, Ralf
dc.date2009-01-30
dc.date.accessioned2026-07-07T13:10:53Z
dc.date.available2026-07-07T13:10:53Z
dc.descriptionTranslocation through a nanopore is a new experimental technique to probe physical properties of biomolecules. A bulk of theoretical and computational work exists on the dependence of the time to translocate a single unstructured molecule on the length of the molecule. Here, we study the same problem but for RNA molecules for which the breaking of the secondary structure is the main barrier for translocation. To this end, we calculate the mean translocation time of single-stranded RNA through a nanopore of zero thickness and at zero voltage for many randomly chosen RNA sequences. We find the translocation time to depend on the length of the RNA molecule with a power law. The exponent changes as a function of temperature and exceeds the naively expected exponent of two for purely diffusive transport at all temperatures. We interpret the power law scaling in terms of diffusion in a one-dimensional energy landscape with a logarithmic barrier.
dc.description21 pages, 7 figures, 1 table
dc.identifierhttps://arxiv.org/abs/0901.4850
dc.identifierhttp://arxiv.org/abs/0901.4850
dc.identifierPhys. Biol. 6 (2009) 036006
dc.identifierdoi:10.1088/1478-3975/6/3/036006
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/229128
dc.subjectBiomolecules
dc.titleAnomalous scaling in nanopore translocation of structured heteropolymers
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