Large-scale Oscillation of Structure-Related DNA Sequence Features in Human Chromosome 21
| dc.creator | Li, Wentian | |
| dc.creator | Miramontes, Pedro | |
| dc.date | 2006-06-14 | |
| dc.date.accessioned | 2026-07-07T07:18:55Z | |
| dc.date.available | 2026-07-07T07:18:55Z | |
| dc.description | Human chromosome 21 is the only chromosome in human genome that exhibits oscillation of (G+C)-content of cycle length of hundreds kilobases (500 kb near the right telomere). We aim at establishing the existence of similar periodicity in structure-related sequence features in order to relate this (G+C)% oscillation to other biological phenomena. The following quantities are shown to oscillate with the same 500kb periodicity in human chromosome 21: binding energy calculated by two sets of dinucleotide-based thermodynamic parameters, AA/TT and AAA/TTT bi-/tri-nucleotide density, 5'-TA-3' dinucleotide density, and signal for 10/11-base periodicity of AA/TT or AAA/TTT. These intrinsic quantities are related to structural features of the double helix of DNA molecules, such as base-pair binding, untwisting/unwinding, stiffness, and a putative tendency for nucleosome formation. | |
| dc.description | submitted to Physical Review E | |
| dc.identifier | https://arxiv.org/abs/q-bio/0606016 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0606016 | |
| dc.identifier | Physical Review E, 74:021912 (2006) | |
| dc.identifier | doi:10.1103/PhysRevE.74.021912 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/114477 | |
| dc.subject | Genomics | |
| dc.title | Large-scale Oscillation of Structure-Related DNA Sequence Features in Human Chromosome 21 | |
| dc.type | text |