Power-law rheology and mechano-sensing in a cytoskeleton model with forced protein unfolding

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dc.creatorHoffman, Brenton D.
dc.creatorMassiera, Gladys
dc.creatorCrocker, John C.
dc.date2005-04-07
dc.date2006-03-18
dc.date.accessioned2026-07-07T06:40:36Z
dc.date.available2026-07-07T06:40:36Z
dc.descriptionWe describe a model of cytoskeletal mechanics based on the force-induced conformational change of protein cross-links in a stressed polymer network. Slow deformation of simulated networks containing cross-links that undergo repeated, serial domain unfolding leads to an unusual state--with many cross-links accumulating near the critical force for further unfolding. Thermal activation of these links gives rise to power-law rheology resembling the previously unexplained mechanical response of living cells. Moreover, we hypothesize that such protein cross-links function as biochemical mechano-sensors of cytoskeletal deformation.
dc.description4 pages, 4 figures, revtex4
dc.identifierhttps://arxiv.org/abs/physics/0504051
dc.identifierhttp://arxiv.org/abs/physics/0504051
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/101432
dc.subjectBiological Physics
dc.subjectSoft Condensed Matter
dc.subjectSubcellular Processes
dc.titlePower-law rheology and mechano-sensing in a cytoskeleton model with forced protein unfolding
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