Mass spectrometry proteomic diagnosis: enacting the validation paradigm

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dc.creatorMertens, Bart J. A.
dc.creatorde Noo, M. E.
dc.creatorTollenaar, R. A. E. M.
dc.creatorDeelder, A. M.
dc.date2005-10-10
dc.date.accessioned2026-07-07T08:07:19Z
dc.date.available2026-07-07T08:07:19Z
dc.descriptionThis paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an `early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent and correct use of validation based evaluation - which is a key requirement to achieve unbiased assessment of the ability of mass spectrometry data for diagnosis in this setting. Strict adherence to validation as a scientific principle will however typically imply that the analyst must make choices. Like all choices in statistical analysis, validation comes at a cost! We present a detailed and extensive discussion of the issues involved and propose that much greater emphasis and requirement for validation would enter clinical proteomic science.
dc.description21 pages, 4 figures, see http://clinicalresearch.nl/personalpage/ for updated info or contact information
dc.identifierhttps://arxiv.org/abs/math/0510188
dc.identifierhttp://arxiv.org/abs/math/0510188
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/130903
dc.subjectStatistics Theory
dc.subjectQuantitative Methods
dc.subject62P10
dc.titleMass spectrometry proteomic diagnosis: enacting the validation paradigm
dc.typetext

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