Multiprotein DNA looping

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dc.creatorVilar, Jose M. G.
dc.creatorSaiz, Leonor
dc.date2006-03-17
dc.date2006-06-19
dc.date.accessioned2026-07-07T07:07:53Z
dc.date.available2026-07-07T07:07:53Z
dc.descriptionDNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.
dc.description11 pages, 4 figures
dc.identifierhttps://arxiv.org/abs/q-bio/0603020
dc.identifierhttp://arxiv.org/abs/q-bio/0603020
dc.identifierPhys. Rev. Lett. 96, 238103 (2006)
dc.identifierdoi:10.1103/PhysRevLett.96.238103
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/110559
dc.subjectSubcellular Processes
dc.subjectStatistical Mechanics
dc.subjectBiological Physics
dc.subjectBiomolecules
dc.titleMultiprotein DNA looping
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