From DNA sequence analysis to modeling replication in the human genome

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dc.creatorBrodie, Edward-Benedict
dc.creatorNicolay, Samuel
dc.creatorTouchon, Marie
dc.creatorAudit, Benjamin
dc.creatorD'Aubenton-Carafa, Yves
dc.creatorThermes, Claude
dc.creatorArneodo, Alain
dc.date2007-10-22
dc.date.accessioned2026-07-07T08:37:44Z
dc.date.available2026-07-07T08:37:44Z
dc.descriptionWe explore the large-scale behavior of nucleotide compositional strand asymmetries along human chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA+GC) skew displays rather sharp upward jumps, with a linear decreasing profile in between two successive jumps. We present a model of replication with well positioned replication origins and random terminations that accounts for the observed characteristic serrated skew profiles. We succeed in identifying 287 pairs of putative adjacent replication origins with an origin spacing approximately 1-2 Mbp that are likely to correspond to replication foci observed in interphase nuclei and recognized as stable structures that persist throughout subsequent cell generations.
dc.identifierhttps://arxiv.org/abs/0710.4030
dc.identifierhttp://arxiv.org/abs/0710.4030
dc.identifierPhysical Review Letters 94, 24 (2005) 248103
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/140502
dc.subjectGenomics
dc.titleFrom DNA sequence analysis to modeling replication in the human genome
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