Statistical mechanics of coil-hairpin transition in a single stranded DNA oligomer

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A model of self-avoiding walk with suitable constraints on self-attraction is developed to describe the conformational behavior of a short RNA or a single stranded DNA molecule that forms hairpin structure and calculate the properties associated with coil-hairpin transition by enumerating all possible conformations of a chain of N monomers in two and three dimensions. The first and last five monomers of the chain have been allowed to pair and form the stem of the hairpin structure while the remaining monomers can form a loop. The coil-hairpin transition is found to be first order with large entropy change. While the rate of unzipping of the hairpin stem is found to be independent of the length of the loop and the dimensionality of the space, the rate of closing varies greatly with loop length and dimensionality of the space.
RevTeX v4, 10 pages with 5 eps figures

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Statistical Mechanics, Soft Condensed Matter, Biological Physics

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http://salesiana.dossiersoluciones.com/handle/123456789/122021

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/cond-mat/0701368
 http://arxiv.org/abs/cond-mat/0701368
 Europhys Lett. 70 (2005) 15-21

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arXiv