Nimesulide limits kainate-induced oxidative damage in the rat hippocampus

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dc.creatorCandelario-Jalil, E.
dc.creatorAjamieh, H. H.
dc.creatorSam, S.
dc.creatorMartinez, G.
dc.creatorLeon, O. S.
dc.date2007-08-14
dc.date.accessioned2026-07-07T08:23:42Z
dc.date.available2026-07-07T08:23:42Z
dc.descriptionKainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p.) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.
dc.identifierhttps://arxiv.org/abs/0708.1971
dc.identifierhttp://arxiv.org/abs/0708.1971
dc.identifierEuropean Journal of Pharmacology 390(3): 295-298 (2000)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/136094
dc.subjectTissues and Organs
dc.titleNimesulide limits kainate-induced oxidative damage in the rat hippocampus
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