Reciprocal best hits are not a logically sufficient condition for orthology

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dc.creatorJohnson, Toby
dc.date2007-06-01
dc.date.accessioned2026-07-07T08:03:51Z
dc.date.available2026-07-07T08:03:51Z
dc.descriptionIt is common to use reciprocal best hits, also known as a boomerang criterion, for determining orthology between sequences. The best hits may be found by blast, or by other more recently developed algorithms. Previous work seems to have assumed that reciprocal best hits is a sufficient but not necessary condition for orthology. In this article, I explain why reciprocal best hits cannot logically be a sufficient condition for orthology. If reciprocal best hits is neither sufficient nor necessary for orthology, it would seem worthwhile to examine further the logical foundations of some unsupervised algorithms that are used to identify orthologs.
dc.identifierhttps://arxiv.org/abs/0706.0117
dc.identifierhttp://arxiv.org/abs/0706.0117
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/129732
dc.subjectGenomics
dc.titleReciprocal best hits are not a logically sufficient condition for orthology
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