The role of microtubule movement in bidirectional organelle transport

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dc.creatorKulić, Igor M.
dc.creatorBrown, André E. X.
dc.creatorKim, Hwajin
dc.creatorKural, Comert
dc.creatorBlehm, Benjamin
dc.creatorSelvin, Paul R.
dc.creatorNelson, Philip C.
dc.creatorGelfand, Vladimir I.
dc.date2008-08-12
dc.date.accessioned2026-07-07T09:56:23Z
dc.date.available2026-07-07T09:56:23Z
dc.descriptionWe study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions. Multiple peroxisomes move in unison over large time windows and show correlations with microtubule tip positions, indicating rapid microtubule fluctuations in the longitudinal direction. We report the first high-resolution measurement of longitudinal microtubule fluctuations performed by tracing such pairs of co-moving peroxisomes. The resulting picture shows that motor-dependent longitudinal microtubule oscillations contribute significantly to cargo movement along microtubules. Thus, contrary to the conventional view, organelle transport cannot be described solely in terms of cargo movement along stationary microtubule tracks, but instead includes a strong contribution from the movement of the tracks.
dc.description24 pages, 5 figures
dc.identifierhttps://arxiv.org/abs/0808.1751
dc.identifierhttp://arxiv.org/abs/0808.1751
dc.identifierProc. Nat. Acad. Sci. (2008) 105:10011-10016
dc.identifierdoi:10.1073/pnas.0800031105
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/166961
dc.subjectBiological Physics
dc.subjectSubcellular Processes
dc.titleThe role of microtubule movement in bidirectional organelle transport
dc.typetext

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