From systems biology to dynamical neuropharmacology: proposal for a new methodology

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dc.creatorErdi, Peter
dc.creatorKiss, Tamas
dc.creatorToth, Janos
dc.creatorUjfalussy, Balazs
dc.creatorZalanyi, Laszlo
dc.date2006-07-20
dc.date.accessioned2026-07-07T07:22:50Z
dc.date.available2026-07-07T07:22:50Z
dc.descriptionThe concepts and methods of Systems Biology are being extended to neuropharmacology, to test and design drugs against neurological and psychiatric disorders. Computational modeling by integrating compartmental neural modeling technique and detailed kinetic description of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electrophysiological and behavioral effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realize a prescribed temporal pattern. In particular, as an application of the proposed new methodology a computational platform is offered to analyze the generation and pharmacological modulation of theta rhythm related to anxiety is analyzed here in more detail.
dc.descriptionFor an opinion paper see: Aradi and Erdi: Computational neuropharmacology: dynamical approaches in drug discovery TRENDS in Pharmacological Sciences 27(5) 240-243
dc.identifierhttps://arxiv.org/abs/q-bio/0607031
dc.identifierhttp://arxiv.org/abs/q-bio/0607031
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/115800
dc.subjectNeurons and Cognition
dc.subjectQuantitative Methods
dc.titleFrom systems biology to dynamical neuropharmacology: proposal for a new methodology
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