The Context Sensitivity Problem in Biological Sequence Segmentation

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dc.creatorCheong, Siew-Ann
dc.creatorStodghill, Paul
dc.creatorSchneider, David J.
dc.creatorCartinhour, Samuel W.
dc.creatorMyers, Christopher R.
dc.date2009-04-17
dc.date.accessioned2026-07-07T13:05:39Z
dc.date.available2026-07-07T13:05:39Z
dc.descriptionIn this paper, we describe the context sensitivity problem encountered in partitioning a heterogeneous biological sequence into statistically homogeneous segments. After showing signatures of the problem in the bacterial genomes of Escherichia coli K-12 MG1655 and Pseudomonas syringae DC3000, when these are segmented using two entropic segmentation schemes, we clarify the contextual origins of these signatures through mean-field analyses of the segmentation schemes. Finally, we explain why we believe all sequence segmentation schems are plagued by the context sensitivity problem.
dc.descriptionIEEEtran class, 39 pages, 20 figures
dc.identifierhttps://arxiv.org/abs/0904.2668
dc.identifierhttp://arxiv.org/abs/0904.2668
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/227556
dc.subjectGenomics
dc.titleThe Context Sensitivity Problem in Biological Sequence Segmentation
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