Robustness and modular design of the Drosophila segment polarity network

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dc.creatorMa, Wenzhe
dc.creatorLai, Luhua
dc.creatorOuyang, Qi
dc.creatorTang, Chao
dc.date2006-10-17
dc.date2006-10-31
dc.date.accessioned2026-07-07T07:39:13Z
dc.date.available2026-07-07T07:39:13Z
dc.descriptionBiomolecular networks have to perform their functions robustly. A robust function may have preferences in the topological structures of the underlying network. We carried out an exhaustive computational analysis on network topologies in relation to a patterning function in Drosophila embryogenesis. We found that while the vast majority of topologies can either not perform the required function or only do so very fragilely, a small fraction of topologies emerges as particularly robust for the function. The topology adopted by Drosophila, that of the segment polarity network, is a top ranking one among all topologies with no direct autoregulation. Furthermore, we found that all robust topologies are modular--each being a combination of three kinds of modules. These modules can be traced back to three sub-functions of the patterning function and their combinations provide a combinatorial variability for the robust topologies. Our results suggest that the requirement of functional robustness drastically reduces the choices of viable topology to a limited set of modular combinations among which nature optimizes its choice under evolutionary and other biological constraints.
dc.descriptionSupplementary Information and Synopsis available at http://www.ucsf.edu/tanglab/
dc.identifierhttps://arxiv.org/abs/q-bio/0610028
dc.identifierhttp://arxiv.org/abs/q-bio/0610028
dc.identifierMolecular Systems Biology 2:70 (2006).
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/121367
dc.subjectMolecular Networks
dc.titleRobustness and modular design of the Drosophila segment polarity network
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