Some protein interaction data do not exhibit power law statistics
| dc.creator | Tanaka, Reiko | |
| dc.creator | Yi, Tau-Mu | |
| dc.creator | Doyle, John | |
| dc.date | 2005-06-27 | |
| dc.date.accessioned | 2026-07-07T06:18:53Z | |
| dc.date.available | 2026-07-07T06:18:53Z | |
| dc.description | It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical analysis. Typically, the supporting data are presented using frequency-degree plots. We show that such plots can be misleading, and should correctly be replaced by rank-degree plots. We provide two PPI network examples in which the frequency-degree plots appear linear on a log-log scale, but the rank-degree plots demonstrate that the node degree sequence is far from a power law. We conclude that at least these PPI networks are not scale-free. | |
| dc.description | 4 pages, 2 figures | |
| dc.identifier | https://arxiv.org/abs/q-bio/0506038 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0506038 | |
| dc.identifier | FEBS Letters 579 (2005) 514--5144 | |
| dc.identifier | doi:10.1016/j.febslet.2005.08.024 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/94890 | |
| dc.subject | Molecular Networks | |
| dc.title | Some protein interaction data do not exhibit power law statistics | |
| dc.type | text |