Effect of Bilayer Thickness on Membrane Bending Rigidity

Bermudez, H.; Hammer, D. A.; Discher, D. E.

Effect of Bilayer Thickness on Membrane Bending Rigidity

Authors

Bermudez, H.

Hammer, D. A.

Discher, D. E.

Description

The bending rigidity $k_c$ of bilayer vesicles self-assembled from amphiphilic diblock copolymers has been measured using single and dual-micropipet techniques. These copolymers are nearly a factor of 5 greater in hydrophobic membrane thickness $d$ than their lipid counterparts, and an order of magnitude larger in molecular weight $\bar{M}_n$. The macromolecular structure of these amphiphiles lends insight into and extends relationships for traditional surfactant behavior. We find the scaling of $k_c$ with thickness to be nearly quadratic, in agreement with existing theories for bilayer membranes. The results here are key to understanding and designing soft interfaces such as biomembrane mimetics.