Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

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dc.creatorWeinberger, Leor S.
dc.creatorBurnett, John C.
dc.creatorToettcher, Jared E.
dc.creatorArkin, Adam P.
dc.creatorSchaffer, David V.
dc.date2006-08-01
dc.date.accessioned2026-07-07T07:26:16Z
dc.date.available2026-07-07T07:26:16Z
dc.descriptionStochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, Weinberger et al. (2005) take an integrated computational-experimental approach to study the Tat transactivation feedback loop in HIV-1 and show that fluctuations in a key regulator, Tat, can result in a phenotypic bifurcation. This phenomenon is observed in an isogenic population where individual cells display two distinct expression states corresponding to latent and productive infection by HIV-1. These findings demonstrate the importance of stochastic gene expression in molecular "decision-making."
dc.descriptionSupplemental data available as q-bio.MN/0608003
dc.identifierhttps://arxiv.org/abs/q-bio/0608002
dc.identifierhttp://arxiv.org/abs/q-bio/0608002
dc.identifierCell. 2005 Jul 29;122(2):169-82
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/117016
dc.subjectMolecular Networks
dc.subjectSoft Condensed Matter
dc.subjectBiological Physics
dc.subjectCell Behavior
dc.titleStochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
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