On the simulation of enzymatic digest patterns: the fragmentation of oligomeric and polymeric galacturonides by endo-polygalacturonase II

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dc.creatorHunt, Jonathan J
dc.creatorCameron, Randall G
dc.creatorWilliams, Martin A. K.
dc.date2006-09-01
dc.date.accessioned2026-07-07T07:25:59Z
dc.date.available2026-07-07T07:25:59Z
dc.descriptionA simulation methodology for predicting the time-course of enzymatic digestions is described. The model is based solely on the enzyme's subsite architecture and concomitant binding energies. This allows subsite binding energies to be used to predict the evolution of the relative amounts of different products during the digestion of arbitrary mixtures of oligomeric or polymeric substrates. The methodology has been specifically demonstrated by studying the fragmentation of a population of oligogalacturonides of varying degrees of polymerization, when digested by endo-polygalacturonase II (endo-PG II) from Aspergillus niger.
dc.descriptionPreprint - has been accepted to Biochimica et Biophysica Acta
dc.identifierhttps://arxiv.org/abs/physics/0609004
dc.identifierhttp://arxiv.org/abs/physics/0609004
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/116918
dc.subjectBiological Physics
dc.titleOn the simulation of enzymatic digest patterns: the fragmentation of oligomeric and polymeric galacturonides by endo-polygalacturonase II
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