Dynamin recruitment by clathrin coats: a physical step?
| dc.creator | Fournier, J. -B. | |
| dc.creator | Dommersnes, P. -G. | |
| dc.creator | Galatola, P. | |
| dc.date | 2003-01-15 | |
| dc.date.accessioned | 2026-07-07T02:49:10Z | |
| dc.date.available | 2026-07-07T02:49:10Z | |
| dc.description | Recent structural findings have shown that dynamin, a cytosol protein playing a key-role in clathrin-mediated endocytosis, inserts partly within the lipid bilayer and tends to self-assemble around lipid tubules. Taking into account these observations, we make the hypothesis that individual membrane inserted dynamins imprint a local cylindrical curvature to the membrane. This imprint may give rise to long-range mechanical forces mediated by the elasticity of the membrane. Calculating the resulting many-body interaction between a collection of inserted dynamins and a membrane bud, we find a regime in which the dynamins are elastically recruited by the bud to form a collar around its neck, which is reminiscent of the actual process preempting vesicle scission. This physical mechanism might therefore be implied in the recruitment of dynamins by clathrin coats. | |
| dc.description | 11 pages, 6 figures, to appear in C.R.A.S. ser III | |
| dc.identifier | https://arxiv.org/abs/cond-mat/0301257 | |
| dc.identifier | http://arxiv.org/abs/cond-mat/0301257 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/20688 | |
| dc.subject | Soft Condensed Matter | |
| dc.subject | Quantitative Biology | |
| dc.title | Dynamin recruitment by clathrin coats: a physical step? | |
| dc.type | text |