Dissecting Subsecond Cadherin Bound States Reveals an Efficient Way for Cells to Achieve Ultrafast Probing of their Environment

Simple item page
dc.creatorPierres, Anne
dc.creatorPrakasam, Anil
dc.creatorTouchard, Dominique
dc.creatorBenoliel, Anne-Marie
dc.creatorBongrand, Pierre
dc.creatorLeckband, Deborah
dc.date2007-09-25
dc.date.accessioned2026-07-07T08:32:08Z
dc.date.available2026-07-07T08:32:08Z
dc.descriptionCells continuously probe their environment with membrane receptors, achieving subsecond adaptation of their behaviour [1-3]. Recently, several receptors, including cadherins, were found to bind ligands with a lifetime of order of one second. Here we show at the single molecule level that homotypic C-cadherin association involves transient intermediates lasting less than a few tens of milliseconds. Further, these intermediates transitionned towards more stable states with a kinetic rate displaying exponential decrease with piconewton forces. These features enable cells to detect ligands or measure surrounding mechanical behaviour within a fraction of a second, much more rapidly than was previously thought.
dc.identifierhttps://arxiv.org/abs/0709.4019
dc.identifierhttp://arxiv.org/abs/0709.4019
dc.identifierFEBS letters 581 (2007) 1841
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/138705
dc.subjectCell Behavior
dc.subjectBiological Physics
dc.titleDissecting Subsecond Cadherin Bound States Reveals an Efficient Way for Cells to Achieve Ultrafast Probing of their Environment
dc.typetext

Files

Collections

arXiv