Dynamic force spectroscopy of DNA hairpins. II. Irreversibility and dissipation

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dc.creatorManosas, Maria
dc.creatorMossa, Alessandro
dc.creatorForns, Nuria
dc.creatorHuguet, Josep Maria
dc.creatorRitort, Felix
dc.date2009-02-20
dc.date.accessioned2026-07-07T12:46:08Z
dc.date.available2026-07-07T12:46:08Z
dc.descriptionWe investigate irreversibility and dissipation in single molecules that cooperatively fold/unfold in a two state manner under the action of mechanical force. We apply path thermodynamics to derive analytical expressions for the average dissipated work and the average hopping number in two state systems. It is shown how these quantities only depend on two parameters that characterize the folding/unfolding kinetics of the molecule: the fragility and the coexistence hopping rate. The latter has to be rescaled to take into account the appropriate experimental setup. Finally we carry out pulling experiments with optical tweezers in a specifically designed DNA hairpin that shows two-state cooperative folding. We then use these experimental results to validate our theoretical predictions.
dc.description28 pages, 12 figures
dc.identifierhttps://arxiv.org/abs/0902.3634
dc.identifierhttp://arxiv.org/abs/0902.3634
dc.identifierJ. Stat. Mech. (2009) P02061
dc.identifierdoi:10.1088/1742-5468/2009/02/P02061
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/221278
dc.subjectStatistical Mechanics
dc.subjectBiological Physics
dc.subjectBiomolecules
dc.subjectQuantitative Methods
dc.titleDynamic force spectroscopy of DNA hairpins. II. Irreversibility and dissipation
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