Sequence Space Localization in the Immune System Response to Vaccination and Disease

Simple item page
dc.creatorDeem, Michael W.
dc.creatorLee, Ha Youn
dc.date2003-08-29
dc.date.accessioned2026-07-07T02:53:11Z
dc.date.available2026-07-07T02:53:11Z
dc.descriptionWe introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can \emph{increase} susceptibility to future exposures to the same disease, is explained as stemming from localization of the immune system response in antibody sequence space. This localization is a result of the roughness in sequence space of the evolved antibody affinity constant for antigen and is observed for diseases with high year-to-year mutation rates, such as influenza.
dc.description5 pages, 2 figures
dc.identifierhttps://arxiv.org/abs/cond-mat/0308613
dc.identifierhttp://arxiv.org/abs/cond-mat/0308613
dc.identifierPhys. Rev. Lett. 91 (2003) 068101
dc.identifierdoi:10.1103/PhysRevLett.91.068101
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/22115
dc.subjectStatistical Mechanics
dc.subjectPopulations and Evolution
dc.titleSequence Space Localization in the Immune System Response to Vaccination and Disease
dc.typetext

Files

Collections

arXiv