Self-organization of gene regulatory network motifs enriched with short transcript's half-life transcription factors
| dc.creator | Wang, Edwin | |
| dc.creator | Purisima, Enrico | |
| dc.date | 2005-04-18 | |
| dc.date | 2005-04-25 | |
| dc.date.accessioned | 2026-07-07T05:59:13Z | |
| dc.date.available | 2026-07-07T05:59:13Z | |
| dc.description | Network motifs, the recurring regulatory structural patterns in networks, are able to self-organize to produce networks. Three major motifs, feedforward loop, single input modules and bi-fan are found in gene regulatory networks. The large ratio of genes to transcription factors (TFs) in genomes leads to a sharing of TFs by motifs and is sufficient to result in network self-organization. We find a common design principle of these motifs: short transcript's half-life (THL) TFs are significantly enriched in motifs and hubs. This enrichment becomes one of the driving forces for the emergence of the network scale-free topology and allows the network to quickly adapt to environmental changes. Most feedforward loops and bi-fans contain at least one short THL TF, which can be seen as a criterion for self-assembling these motifs. We have classified the motifs according to their short THL TF content. We show that the percentage of the different motif subtypes varies in different cellular conditions. | |
| dc.description | Trends Genet (in press), main text 1, supplementary notes 1, 40 pages, 7 tables, 4 figs, minor modifications | |
| dc.identifier | https://arxiv.org/abs/q-bio/0504025 | |
| dc.identifier | http://arxiv.org/abs/q-bio/0504025 | |
| dc.identifier | Trends Genet, 21:492-495, 2005 | |
| dc.identifier | doi:10.1016/j.tig.2005.06.013 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/88600 | |
| dc.subject | Molecular Networks | |
| dc.title | Self-organization of gene regulatory network motifs enriched with short transcript's half-life transcription factors | |
| dc.type | text |