How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells

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dc.creatorJo, J.
dc.creatorKang, H.
dc.creatorChoi, M. Y.
dc.creatorKoh, D. S.
dc.date2005-09-05
dc.date.accessioned2026-07-07T05:59:26Z
dc.date.available2026-07-07T05:59:26Z
dc.descriptionUnlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells,with heterogeneity induced by noise, to find that it enhances regular bursts.
dc.description40 pages, 10 figures
dc.identifierhttps://arxiv.org/abs/q-bio/0509004
dc.identifierhttp://arxiv.org/abs/q-bio/0509004
dc.identifierpublished in Biophysical Journal 89:1534-1542 (2005)
dc.identifierdoi:10.1529/biophysj.104.053181
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88679
dc.subjectCell Behavior
dc.subjectBiological Physics
dc.titleHow Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells
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