One Hub-One Process: A Tool Based View on Regulatory Network Topology

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dc.creatorAxelsen, Jacob Bock
dc.creatorBernhardsson, Sebastian
dc.creatorSneppen, Kim
dc.date2007-11-14
dc.date2007-11-29
dc.date.accessioned2026-07-07T09:24:11Z
dc.date.available2026-07-07T09:24:11Z
dc.descriptionThe relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. This suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.
dc.description18 pages, 3 figures, 5 supplementary figures
dc.identifierhttps://arxiv.org/abs/0711.2208
dc.identifierhttp://arxiv.org/abs/0711.2208
dc.identifierBMC Systems Biology 2008, 2:25
dc.identifierdoi:10.1186/1752-0509-2-25
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/156005
dc.subjectMolecular Networks
dc.subjectSoft Condensed Matter
dc.titleOne Hub-One Process: A Tool Based View on Regulatory Network Topology
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