Quantitative approach to facilitated diffusion with intersegmental jumping

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dc.creatorLomholt, Michael A.
dc.creatorBroek, Bram van den
dc.creatorKalisch, Svenja-Marei J.
dc.creatorWuite, Gijs J. L.
dc.creatorMetzler, Ralf
dc.date2008-12-16
dc.date.accessioned2026-07-07T13:16:18Z
dc.date.available2026-07-07T13:16:18Z
dc.descriptionWe study the impact of DNA coiling on the search rate of proteins moving along the DNA contour interspersed by three-dimensional (3D) bulk excursions. When the DNA is coiled proteins performing short 3D hops along a DNA segment can be captured by foreign DNA segments that have looped back close to the original segment. These intersegmental jumps are shown to enhance the search rate for a specific site on the DNA by lowering the tendency to resample previously visited sites on the DNA. The model developed here offers a quantitative description of recent single molecule experiments on facilitated diffusion of restriction enzymes EcoRV.
dc.description4 pages, 2 figures, REVTeX
dc.identifierhttps://arxiv.org/abs/0812.3109
dc.identifierhttp://arxiv.org/abs/0812.3109
dc.identifierProc. Natl. Acad. Sci. USA 106, 8204 (2009)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/230746
dc.subjectStatistical Mechanics
dc.subjectBiomolecules
dc.titleQuantitative approach to facilitated diffusion with intersegmental jumping
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