Controlled Clustering of Superparamagnetic Nanoparticles using Block Copolymers : Design of New Contrast Agents for Magnetic Resonance Imaging

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dc.creatorBerret, Jean-Francois
dc.creatorSchonbeck, Nicolas
dc.creatorGazeau, Florence
dc.creatorKharrat, Delphine El
dc.creatorSandre, Olivier
dc.creatorVacher, Annie
dc.creatorAiriau, Marc
dc.date2005-12-12
dc.date.accessioned2026-07-07T08:28:15Z
dc.date.available2026-07-07T08:28:15Z
dc.descriptionWhen polyelectrolyte-neutral block copolymers are mixed in aqueous solutions with oppositely charged species, stable complexes are found to form spontaneously. The mechanism is based on electrostatics, and on the compensation between the opposite charges. Electrostatic complexes exhibit a core-shell microstructure. In the core, the polyelectrolyte blocks and the oppositely charged species are tightly bound and form a dense coacervate microphase. The shell is made of the neutral chains and surrounds the core. In this paper, we report on the structural and magnetic properties of such complexes made from 6.3 nm diameter superparamagnetic nanoparticles (maghemite gamma-Fe2O3) and cationic-neutral copolymers. The copolymers investigated are poly(trimethylammonium ethylacrylate methylsulfate)-b-poly(acrylamide), with molecular weights 5000-b-30000 gmol-1 and 110000-b-30000 gmol-1. The mixed copolymer-nanoparticle aggregates were characterized by a combination of light scattering and cryo-transmission electron microscopy. Their hydrodynamic diameters were found in the range 70 - 150 nm and their aggregation numbers (number of nanoparticles per aggregate) between several tens to several hundreds. In addition, Magnetic Resonance Spin-Echo measurements show that the complexes have a better contrast in Magnetic Resonance Imaging than single nanoparticles, and that these complexes could be used for biomedical applications.
dc.description7 figures, 7 pages, 52 references
dc.identifierhttps://arxiv.org/abs/cond-mat/0512251
dc.identifierhttp://arxiv.org/abs/cond-mat/0512251
dc.identifierJ. Am. Chem. Soc., 128 (5), 1755 -1761, 2006
dc.identifierdoi:10.1021/ja0562999
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/137549
dc.subjectSoft Condensed Matter
dc.subjectMaterials Science
dc.titleControlled Clustering of Superparamagnetic Nanoparticles using Block Copolymers : Design of New Contrast Agents for Magnetic Resonance Imaging
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