Kinetic proofreading of gene activation by chromatin remodeling

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dc.creatorBlossey, Ralf
dc.creatorSchiessel, Helmut
dc.date2008-01-09
dc.date2008-04-28
dc.date.accessioned2026-07-07T09:35:13Z
dc.date.available2026-07-07T09:35:13Z
dc.descriptionGene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodellers and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.
dc.description8 pages, 2 Figures; application added
dc.identifierhttps://arxiv.org/abs/0801.1386
dc.identifierhttp://arxiv.org/abs/0801.1386
dc.identifierdoi:10.2976/1.2909080
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/159760
dc.subjectMolecular Networks
dc.subjectBiomolecules
dc.titleKinetic proofreading of gene activation by chromatin remodeling
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