Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

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dc.creatorKäfer, Jos
dc.creatorHayashi, Takashi
dc.creatorMarée, Athanasius F. M.
dc.creatorCarthew, Richard W.
dc.creatorGraner, François
dc.date2007-05-08
dc.date2007-09-05
dc.date.accessioned2026-07-07T08:42:46Z
dc.date.available2026-07-07T08:42:46Z
dc.descriptionHayashi and Carthew (Nature 431 [2004], 647) have shown that the packing of cone cells in the Drosophila retina resembles soap bubble packing, and that changing E- and N-cadherin expression can change this packing, as well as cell shape. The analogy with bubbles suggests that cell packing is driven by surface minimization. We find that this assumption is insufficient to model the experimentally observed shapes and packing of the cells based on their cadherin expression. We then consider a model in which adhesion leads to a surface increase, balanced by cell cortex contraction. Using the experimentally observed distributions of E- and N-cadherin, we simulate the packing and cell shapes in the wildtype eye. Furthermore, by changing only the corresponding parameters, this model can describe the mutants with different numbers of cells, or changes in cadherin expression.
dc.descriptionrevised manuscript; 8 pages, 6 figures; supplementary information not included
dc.identifierhttps://arxiv.org/abs/0705.1057
dc.identifierhttp://arxiv.org/abs/0705.1057
dc.identifierProc. Natl. Acad. Sci. U.S.A. (2007), 104 (47), 18549-18554
dc.identifierdoi:10.1073/pnas.0704235104
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/142077
dc.subjectCell Behavior
dc.subjectTissues and Organs
dc.titleCell adhesion and cortex contractility determine cell patterning in the Drosophila retina
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