Comment of Global dynamics of biological systems
| dc.creator | Nagarajan, Radhakrishnan | |
| dc.date | 2008-06-20 | |
| dc.date.accessioned | 2026-07-07T09:46:01Z | |
| dc.date.available | 2026-07-07T09:46:01Z | |
| dc.description | In a recent study, (Grigorov, 2006) analyzed temporal gene expression profiles (Arbeitman et al., 2002) generated in a Drosophila experiment using SSA in conjunction with Monte-Carlo SSA. The author (Grigorov, 2006) makes three important claims in his article, namely: Claim1: A new method based on the theory of nonlinear time series analysis is used to capture the global dynamics of the fruit-fly cycle temporal gene expression profiles. Claim 2: Flattening of a significant part of the eigen-spectrum confirms the hypothesis about an underly-ing high-dimensional chaotic generating process. Claim 3: Monte-Carlo SSA can be used to establish whether a given time series is distinguishable from any well-defined process including deterministic chaos. In this report we present fundamental concerns with respect to the above claims (Grigorov, 2006) in a systematic manner with simple examples. The discussion provided especially discourages the choice of SSA for inferring nonlinear dynamical structure form time series obtained in any biological paradigm. | |
| dc.description | 6 pages, 2 figures | |
| dc.identifier | https://arxiv.org/abs/0806.3479 | |
| dc.identifier | http://arxiv.org/abs/0806.3479 | |
| dc.identifier.uri | http://salesiana.dossiersoluciones.com/handle/123456789/163390 | |
| dc.subject | Genomics | |
| dc.title | Comment of Global dynamics of biological systems | |
| dc.type | text |