Reduction to the Simplest - The Complexity of Minimalistic Heteropolymer Models

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Simple coarse-grained hydrophobic-polar models for heteropolymers as the lattice HP and the off-lattice AB model allow a general classification of characteristic behaviors for hydrophobic-core based tertiary folding. The strongly reduced computational efforts enable one to reveal systematically the thermodynamic properties of comparatively long sequences in a wide temperature range of conformational activity. Based on a suitable cooperativity parameter, characteristic folding channels and free-energy landscapes, which have strong similarities with realistic folding paths, can be analysed.
3 pages, 1 figure

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Soft Condensed Matter, Biological Physics

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http://salesiana.dossiersoluciones.com/handle/123456789/140683

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/0710.4353
 http://arxiv.org/abs/0710.4353
 in: Proceedings of the NIC Workshop 2006 "From Computational Biophysics to Systems Biology", NIC Series vol. 34 (NIC, Juelich, 2006), pp. 59-61

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