Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation

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dc.creatorLemaire, Vincent
dc.creatorLee, Chiu Fan
dc.creatorLei, Jinzhi
dc.creatorMetivier, Raphael
dc.creatorGlass, Leon
dc.date2006-05-30
dc.date.accessioned2026-07-07T07:15:14Z
dc.date.available2026-07-07T07:15:14Z
dc.descriptionIn human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps.
dc.identifierhttps://arxiv.org/abs/q-bio/0605049
dc.identifierhttp://arxiv.org/abs/q-bio/0605049
dc.identifierPhys. Rev. Lett. 96, 198102 (2006)
dc.identifierdoi:10.1103/PhysRevLett.96.198102
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/113189
dc.subjectCell Behavior
dc.subjectMolecular Networks
dc.titleSequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation
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