Structurally specific thermal fluctuations identify functional sites for DNA transcription

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dc.creatorKalosakas, G.
dc.creatorRasmussen, K. Ø.
dc.creatorBishop, A. R.
dc.creatorChoi, C. H.
dc.creatorUsheva, A.
dc.date2003-09-05
dc.date2003-09-09
dc.date.accessioned2026-07-07T06:28:36Z
dc.date.available2026-07-07T06:28:36Z
dc.descriptionWe report results showing that thermally-induced openings of double stranded DNA coincide with the location of functionally relevant sites for transcription. Investigating both viral and bacterial DNA gene promoter segments, we found that the most probable opening occurs at the transcription start site. Minor openings appear to be related to other regulatory sites. Our results suggest that coherent thermal fluctuations play an important role in the initiation of transcription. Essential elements of the dynamics, in addition to sequence specificity, are nonlinearity and entropy, provided by local base-pair constraints.
dc.identifierhttps://arxiv.org/abs/cond-mat/0309157
dc.identifierhttp://arxiv.org/abs/cond-mat/0309157
dc.identifierEUROPHYSICS LETTERS 68, 127-133 (2004)
dc.identifierdoi:10.1209/epl/i2004-10167-8
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/97749
dc.subjectSoft Condensed Matter
dc.subjectBiological Physics
dc.subjectGenomics
dc.titleStructurally specific thermal fluctuations identify functional sites for DNA transcription
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