The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

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dc.creatorCandelario-Jalil, E.
dc.creatorAlvarez, D.
dc.creatorCastaneda, J. M.
dc.creatorAl-Dalain, S. M.
dc.creatorMartinez-Sanchez, G.
dc.creatorMerino, N.
dc.creatorLeon, O. S.
dc.date2007-08-03
dc.date.accessioned2026-07-07T08:22:13Z
dc.date.available2026-07-07T08:22:13Z
dc.descriptionSeveral studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury.
dc.identifierhttps://arxiv.org/abs/0708.0581
dc.identifierhttp://arxiv.org/abs/0708.0581
dc.identifierBrain Research 927(2): 212-215 (2002)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/135576
dc.subjectTissues and Organs
dc.titleThe highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
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