Label-free electrical quantification of the dielectrophoretic response of DNA

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dc.creatorHenning, Anja
dc.creatorHenkel, Joerg
dc.creatorBier, Frank F
dc.creatorHoelzel, Ralph
dc.date2009-01-19
dc.date.accessioned2026-07-07T12:31:36Z
dc.date.available2026-07-07T12:31:36Z
dc.descriptionA purely electrical sensing scheme is presented that determines the concentration of macromolecules in solution by measuring the capacitance between planar microelectrodes. Concentrations of DNA in the ng/mL range have been used in samples of 1 microL volume. The method has been applied to the characterisation of the dielectrophoretic response of DNA without the need for any chemical modifications. The influence of electrical parameters like duty cycle, voltage and frequency has been investigated. The results are in good agreement with data from dielectrophoretic studies on fluorescently labelled DNA. Extension of the method down to the single molecule level appears feasible.
dc.description12 pages, 7 figures
dc.identifierhttps://arxiv.org/abs/0901.2827
dc.identifierhttp://arxiv.org/abs/0901.2827
dc.identifierPMC Biophysics 2008, 1:4
dc.identifierdoi:10.1186/1757-5036-1-4
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/216499
dc.subjectBiological Physics
dc.titleLabel-free electrical quantification of the dielectrophoretic response of DNA
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