Vibrational Infrared Lifetime of the Anesthetic nitrous oxide gas in solution

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dc.creatorChieffo, Logan
dc.creatorAmsden, Jason J.
dc.creatorShattuck, Jeffrey
dc.creatorHong, Mi K.
dc.creatorZiegler, Lawrence
dc.creatorErramilli, Shyamsunder
dc.date2007-05-07
dc.date.accessioned2026-07-07T07:59:44Z
dc.date.available2026-07-07T07:59:44Z
dc.descriptionThe lifetime of the asymmetric fundamental stretching 2218 cm$^{-1}$ vibration of the anesthetic gas nitrous oxide (N$_2$O) dissolved in octanol and olive oil is reported. These solvents are model systems commonly used to assess anesthetic potency. Picosecond time-scale molecular dynamics simulations have suggested that protein dynamics or membrane dynamics play a role in the molecular mechanism of anesthetic action. Ultrafast infrared spectroscopy with 100 fs time resolution is an ideal tool to probe dynamics of anesthetic molecules on such timescales. Pump-probe studies at the peak of the vibrational band yield a lifetime of $55 \pm 1$ ps in olive oil and $52 \pm 1 ps$ in octanol. The similarity of lifetimes suggests that energy relaxation of the anesthetic is determined primarily by the hydrophobic nature of the environment, consistent with models of anesthetic action. The results show that nitrous oxide is a good model system for probing anesthetic-solvent interactions using nonlinear infrared spectroscopy.
dc.description7 pages, 3 Figures, Presented at Biophysics conference in Singapore 2005
dc.identifierhttps://arxiv.org/abs/0705.0835
dc.identifierhttp://arxiv.org/abs/0705.0835
dc.identifierBiophysical Review Letters, 1:309-316 (2006)
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/128481
dc.subjectBiological Physics
dc.subjectChemical Physics
dc.titleVibrational Infrared Lifetime of the Anesthetic nitrous oxide gas in solution
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