A Chemical Kinetic Model of Transcriptional Elongation

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A chemical kinetic model of the elongation dynamics of RNA polymerase along a DNA sequence is introduced. The proposed model governs the discrete movement of the RNA polymerase along a DNA template, with no consideration given to elastic effects. The model's novel concept is a ``look-ahead'' feature, in which nucleotides bind reversibly to the DNA prior to being incorporated covalently into the nascent RNA chain. Results are presented for specific DNA sequences that have been used in single-molecule experiments of the random walk of RNA polymerase along DNA. By replicating the data analysis algorithm from the experimental procedure, the model produces velocity histograms, enabling direct comparison with these published results.
9 pages, 3 figures, 1 table. Corrected typos; condensed size of manuscript to meet PRL submission guidelines. Details in previous edition

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Biomolecules, Subcellular Processes

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http://salesiana.dossiersoluciones.com/handle/123456789/110553

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/q-bio/0603012
 http://arxiv.org/abs/q-bio/0603012

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arXiv