An Exact Model of Fluctuations in Gene Expression

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dc.creatorChen, William W.
dc.creatorEngland, Jeremy L.
dc.creatorShakhnovich, Eugene I.
dc.date2004-02-10
dc.date.accessioned2026-07-07T05:58:13Z
dc.date.available2026-07-07T05:58:13Z
dc.descriptionFluctuations in the measured mRNA levels of unperturbed cells under fixed conditions have often been viewed as an impediment to the extraction of information from expression profiles. Here, we argue that such expression fluctuations should themselves be studied as a source of valuable information about the underlying dynamics of genetic networks. By analyzing microarray data taken from Saccharomyces cerevisiae, we demonstrate that correlations in expression fluctuations have a highly statistically significant dependence on gene function, and furthermore exhibit a remarkable scale-free network structure. We therefore present what we view to be the simplest phenomenological model of a genetic network which can account for the presence of biological information in transcript level fluctuations. We proceed to exactly solve this model using a path integral technique and derive several quantitative predictions. Finally, we propose several experiments by which these predictions might be rigorously tested.
dc.description15 pages, 2 figures, RevTeX4
dc.identifierhttps://arxiv.org/abs/q-bio/0402021
dc.identifierhttp://arxiv.org/abs/q-bio/0402021
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/88274
dc.subjectMolecular Networks
dc.subjectSoft Condensed Matter
dc.titleAn Exact Model of Fluctuations in Gene Expression
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