Modeling thalamocortical cell: impact of Ca2+ channel distribution and cell geometry on firing pattern

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dc.creatorZomorrodi, Reza
dc.creatorKroger, Helmut
dc.creatorTimofeev, Igor
dc.date2009-02-20
dc.date.accessioned2026-07-07T12:45:07Z
dc.date.available2026-07-07T12:45:07Z
dc.descriptionThe influence of calcium channel distribution and geometry of the thalamocortical cell upon its tonic firing and the low threshold spike (LTS) generation was studied in a 3-compartment model, which represents soma, proximal and distal dendrites as well as in multi-compartment model using the morphology of a real reconstructed neuron. Using an uniform distribution of Ca2+ channels, we determined the minimal number of low threshold voltage-activated calcium channels and their permeability required for the onset of LTS in response to a hyperpolarizing current pulse. In the 3-compartment model, we found that the channel distribution influences the firing pattern only in the range of 3% below the threshold value of total T-channel density. In the multi-compartmental model, the LTS could be generated by only 64% of unequally distributed T-channels compared to the minimal number of equally distributed T-channels. For a given channel density and injected current, the tonic firing frequency was found to be inversely proportional to the size of the cell. However, when the Ca2+ channel density was elevated in soma or proximal dendrites, then the amplitude of LTS response and burst spike frequencies were determined by the ratio of total to threshold number of T-channels in the cell for a specific geometry.
dc.identifierhttps://arxiv.org/abs/0902.3654
dc.identifierhttp://arxiv.org/abs/0902.3654
dc.identifierFrontiers Comput. Neurosci, Dec. 2008, Vol.2, Article 5
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/220993
dc.subjectNeurons and Cognition
dc.titleModeling thalamocortical cell: impact of Ca2+ channel distribution and cell geometry on firing pattern
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