On the optimal contact potential of proteins

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We analytically derive the lower bound of the total conformational energy of a protein structure by assuming that the total conformational energy is well approximated by the sum of sequence-dependent pairwise contact energies. The condition for the native structure achieving the lower bound leads to the contact energy matrix that is a scalar multiple of the native contact matrix, i.e., the so-called Go potential. We also derive spectral relations between contact matrix and energy matrix, and approximations related to one-dimensional protein structures. Implications for protein structure prediction are discussed.
5 pages, text only

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Biomolecules, Biological Physics, Chemical Physics

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http://salesiana.dossiersoluciones.com/handle/123456789/145055

Consulte el texto completo en el siguiente enlace:

https://arxiv.org/abs/0709.0346
 http://arxiv.org/abs/0709.0346
 Chemical Physics Letters, Vol. 451 pp. 132-135 (2008)
 doi:10.1016/j.cplett.2007.12.005

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arXiv