Lateral diffusion of receptor-ligand bonds in membrane adhesion zones: Effect of thermal membrane roughness

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dc.creatorKrobath, H.
dc.creatorSchuetz, G. J.
dc.creatorLipowsky, R.
dc.creatorWeikl, T. R.
dc.date2007-03-19
dc.date.accessioned2026-07-07T07:52:27Z
dc.date.available2026-07-07T07:52:27Z
dc.descriptionThe adhesion of cells is mediated by membrane receptors that bind to complementary ligands in apposing cell membranes. It is generally assumed that the lateral diffusion of mobile receptor-ligand bonds in membrane-membrane adhesion zones is slower than the diffusion of unbound receptors and ligands. We find that this slowing down is not only caused by the larger size of the bound receptor-ligand complexes, but also by thermal fluctuations of the membrane shape. We model two adhering membranes as elastic sheets pinned together by receptor-ligand bonds and study the diffusion of the bonds using Monte Carlo simulations. In our model, the fluctuations reduce the bond diffusion constant in planar membranes by a factor close to 2 in the biologically relevant regime of small bond concentrations.
dc.description6 pages, 5 figures; to appear in Europhysics Letters
dc.identifierhttps://arxiv.org/abs/cond-mat/0703491
dc.identifierhttp://arxiv.org/abs/cond-mat/0703491
dc.identifier.urihttp://salesiana.dossiersoluciones.com/handle/123456789/125887
dc.subjectSoft Condensed Matter
dc.titleLateral diffusion of receptor-ligand bonds in membrane adhesion zones: Effect of thermal membrane roughness
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